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Browsing by Subject "Polyketide synthases"

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Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species

Trottmann, Felix; Franke, Jakob; Richter, Ingrid; Ishida, Keishi; Cyrulies, Michael; Dahse, Hans-Martin; Regestein, Lars; Hertweck, Christian (Weinheim : Wiley-VCH Verlag, 2019)

Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While ...
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis

Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)

Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Yang, Xiao-Long; Friedrich, Steffen; Yin, Sen; Piech, Oliver; Williams, Katherine; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2019)

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide ...
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Roberts, Douglas M.; Bartel, Christoph; Scott, Alan; Ivison, David; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2017)

A cis-acting enoyl reductase (ER) catalytic domain was isolated from a fungal highly reducing iterative polyketide synthase (HR-iPKS) for the first time and studied in vitro. The ER from the squalestatin tetraketide synthase ...

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Browsing by Subject "Polyketide synthases"

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